Herbal Medicine

The purpose observes catalpa alcohol and small Bo are alkaline reach its conpatibility of medicines adipose cell dextrose uses up right Saimisong’s revulsive insulin resistance 3T3-L1, activation of object hyperplasia content oxidizes to accept put oneself in another’s position too in have a change of luck and this one process (PPAR- γ ) the influence that MRNA conveys. The method uses rice of ground a place of strategic importance model of cell of resistance of loose revulsive insulin, give ketone of Luo Ge row, small Bo alkaline, catalpa alcohol, catalpa alcohol respectively small Bo is alkaline undertake intervention, with dextrose oxidation enzymatic law detects wastage of the dextrose in fostering fluid, with 2- to oxigenate - [the rate of have a change of luck that 3H]-D- dextrose absorbs a law to observe dextrose, detect with RT-PCR the expression of PPAR- γ MRNA. Below the requirement that the result is contained or does not contain 10 nmol/L insulin, catalpa alcohol, small Bo is alkaline reach insulin of group of its conpatibility of medicines to resist the dextrose wastage of adipose cell and have a change of luck are led relatively model group is improved apparently (P ＜ 0.05, 0.01) , excel of effect of group of conpatibility of medicines is catalpa alcohol, small group of drug of Bo alkaline sheet (P ＜ 0.05, 0.01); and the expression of small Bo alkaline group and MRNA of γ of PPAR- of group of conpatibility of medicines is reduced (P ＜ 0.05, 0.01) . Conclusion catalpa alcohol, small Bo is alkaline all can increase dextrose to use up with have a change of luck, improve insulin resistance, its action does not depend on the existence of insulin, and small Bo is alkaline the expressive level that reachs two medicine conpatibility of medicines to still can reduce MRNA of γ of adipose cell PPAR- , clew catalpa alcohol, small Bo is alkaline likelihood and Luo Ge list the action mechanism that improves insulin resistance ketone is different.

Li of purpose research Ting child water carries fluid to be opposite different third adrenalin (ISO) causes small rat, l- thyroid element (the effect that L-Thy) causes ventricle of bandicoot experiment sex to reframe. Methodological small rat everyday Sc ISO 2 Mg/kg, bandicoot of successive 7 D; everyday Ip L-Thy 0.3 Mg/kg, successive 10 d, preparation ventricle reframes animal model. Each groups of small rat everyday Ig Ting Li child water carries fluid 6, 12 G/kg and beauty hold Luo Er 0.06 G/kg in the palm, after successive 7 d, detect adenosine of phosphoric acid of heart index, serous annulus (blood-vessel of CAMP) , cardiac muscle is nervous element Ⅱ (Ang Ⅱ ) the metabolic; of the quantity each groups of bandicoot everyday Ig Ting Li child water carries fluid 4, 8 g/kg and Katuopuli after 0.02g/kg 10 D, detect ketone of solid of the aldehyde in heart index, plasma (proline of ALD) and Ⅱ of Ang of left cardiac muscle, hydroxide (the change that Hyp) measures. Quantity of Ⅱ of the heart index of result model small rat, CAMP, Ang all lifts apparently, give beautiful Tuoluoer 0.06 g/kg or Ting Li child water carries fluid 12 G/kg to all can restrain small rat Zun Xin room to reframe with fleshy, the amount that reduces heart index and serum CAMP level and Ⅱ of cardiac muscle Ang (P ＜ 0.05) . Model bandicoot also appears cardiac muscle fiber is changed, quantity of Hyp of Ⅱ of Ang of heart index, cardiac muscle, serous ALD, cardiac muscle all lifts apparently, give Katuopuli 0.02 g/kg or Ting Li child water carries fluid 4, 8 G/kg all can reduce bandicoot heart index and Ang Ⅱ , ALD and level of cardiac muscle Hyp (P ＜ 0.05) . Conclusion Ting Li child water carries fluid to have the effect that restrains hypertrophy of experimental animal cardiac muscle, ventricle to reframe, its action mechanism likelihood and control sympathetic system stimulant reach restrain the nerve such as Ang Ⅱ , ALD endocrine factor activation is concerned.

Purpose application medicine is moved learn to learn to combine a model with medical effect, watch of the bases in total alkaloid of research board blue root is accused according to spring the medicine inside body of the yeasty bandicoot that send heat is moved learn to learn the relation between with medical effect. The method gives bandicoot total alkaloid of Ig board blue root, different time takes blood and have observation to temperature, use doctrine of concentrated juice look to determine the watch in plasma is accused according to spring chroma, with model of one room room computational medicine is moved learn parameter, use 3 kinds of medicine to move learn to learn to plan to combine a model with medical effect, learn parameter to undertake planning to close to medical effect respectively. As a result the watch is accused according to spring the main medicine inside normal bandicoot and calorific bandicoot body is moved learn parameter T1/2, Cmax, AUC to be respectively: (4.94 ± 0.84)h, (G/mL of μ of 4.01 ± 0.21) , (H/mL of · of G of μ of 28.37 ± 2.42) and (5.71 ± 0.91)h, (G/mL of μ of 4.15 ± 0.25) , (H/mL of · of G of μ of 30.35 ± 2.58) . It is better that the relation between pharmacodynamics effect and effect room chroma uses the medical effect generation in indirect reaction to restrain a model to plan to close, corresponding medical effect learns parameter to be for Kin respectively (0.7 ± 0.10)h-1, kout is (0.54 ± 0.12)h-1, r0 is 1.33 ± 0.16, IC50 is (0.94 ± 0.66)mg/L. The watch in total alkaloid of conclusion board blue root is accused according to spring the medicine inside normal bandicoot and calorific bandicoot body is moved learn behavior not to have apparent difference, the watch is accused according to spring inside calorific bandicoot body medicine is moved learn to learn a medical effect generation in according with indirect reaction to restrain a model with medical effect.

The purpose discusses a kind new ginseng is rare black glucoside 20-O-(β - dextrose of D- Bi Nan) - 20(S)- protoplast joins glucoside of 2 mellow black (IH-901) is right the hyperplasia of cell of BEL-7402 of person liver cancer restrains the effect and revulsive wither to die action. Method with 0, 6.25, 12.5, 25, 50, 75, the IH-901 action of 100 μ Mol/L the BEL-7402 cell at the education outside body, detect through MTT law the inhibition that IH-901 grows to the cell, differ configuration of microscope observation cell changes, the fluorescent nucleus coloring of AO/EB observes wither dies cellular configuration, art of cell drifting type detects cellular cycle and cellular wither die. Result MTT experiment shows IH-901 restrains the growth of BEL-7402 cell, observe typical wither dies below the means; microscope that shows time and chroma to depend on configuration change and biochemical feature: Go to  to wade agglomeration of? nucleus chromatin, occurrence wither dies after the fluorescent nucleus coloring of small system;AO/EB, observe typical wither dies cellular; sheds type cell appearance to be able to detect to wither die peak, and the cell is in by block sluggish G0/G1 period. The means that conclusion IH-901 can die through revulsive cell wither restrains the growth of cell of BEL-7402 of person liver cancer effectively, IH-901 of glucoside of rare ginseng black may become a kind to fight medicaments of cancer of the liver potentially.

Eggplant Buddhist nun is mellow (Solanesol) is one kind fourfold half terpene Xi is mellow, have fight bacterium, antiphlogistic, hemostatic wait for pharmacodynamics action, regard a kind of medicine as intermediate body at the same time, it is K2 mixes synthetic vitamin complementary the important raw material of enzymatic Q10. Eggplant Buddhist nun is contained in tobacco leaf, potato leaf mellow, tobacco leaf is machining the quantity with mellow Buddhist nun of the eggplant in the process to won’t follow treatment process to produce marked change commonly, this discards to use nicotian industry raw material produces eggplant Buddhist nun mediumly alcohol offerred a possibility.

Colophony of adsorption of purpose research large hole is rarefied n/bot glossy privet child in Qi Dunguo acid and Xiong Guo’s acerbity dynamic adsorption and desorption craft, provide reference for industrialized production. The method uses law of color atlas of concentrated juice photograph to determine acid of neat mound fruit and Xiong Guo’s acerbity quantity; apply static adsorption and desorption experiment to undertake filtration to colophony model, actor of experiment of combinative only factor chooses n/bot glossy privet child Qi Dunguo acid and Xiong Guo’s acerbity rarefied operation condition. Result HPD-100 colophony is acerbity to Qi Dunguo as better as function of Xiong Guo’s acerbity adsorption and desorption; optimizes a condition adsorptively to be colophony bed blade diameter length ratio 1: 6, makings fluid crude drug of mass concentration 0.20 g() / ML, bulk discharge 2 BV/h and colophony of adsorptive capacity 2.4 ML/g() condition of; optimal desorption divides several 80 ﹪ for alcohol bulk, bulk discharge 2 BV/h and solvent dosage Xiong Guo’s acerbity, acerbity quality mark is the Qi Dunguo in 4 BV; product respectively 25.21 ﹪ , 15.65 ﹪ , move rate amounts to 98.64 ﹪ , 98.58 ﹪ respectively. Conclusion HPD-100 but effectively rich collect, rarefied n/bot glossy privet child in Qi Dunguo acid and Xiong Guo are acerbity.

Tea of 8 flavour the root of red-rooted salvia is blindly collect tradition is classical drink of square the root of red-rooted salvia elite of Fang Zhi of bolus of home remedy of celestial being of square, ground, 2 essence is tasted at the health care of own research and development of an organic whole, by river south the root of red-rooted salvia of abundant of medicinal material of city talk ground and hawkthorn are given priority to wait for 8 flavour to rare and feral medicinal material refines and be become, have the effect such as fat of apparent tall blood of prevention and cure, hypertension and fatty liver.

The purpose studies the different accelerant that appear a skin is clever to Bao Xie the permeates via the skin outside system of class status of each index sex influence in extracting content, the sieve singles out the effective sorbefacient that appear a skin. The method uses improved Franz to diffuse pool, it is the protective screen that appear a skin in order to leave body bandicoot skin, through sturdy produce the expected result is being shown outside body, determine with law of color atlas of concentrated juice photograph different permeate accelerant to be opposite in extracting content class status of each index sex the fruit of medicinal cornal second of phenol of alkaline, clove and cinnamonic aldehyde accumulate permeate the quantity, effect that the skin shows to absorb kinetic parameter outside appearing a skin to permeate rate to wait for body. Ketone of nitrogen of result small proportion, and when 2 alcohol use ketone of 3 ﹪ nitrogen and different scale third jointly accumulate permeate a quantity to all have rise apparently, among them with ketone of 3 ﹪ nitrogen the hurried ooze action when 2 alcohol regard 10 ﹪ third as compound accelerant is the strongest. Conclusion permeates accelerant to extract content to spirit of treasure have diarrhoea through making an on-the-spot investigation the influence of class status of each index sex, provided referenced basis to medicine to study its appear a skin.

Purpose research departs from inside yew mellow extract the method of yew alcohol. The method uses high speed technology of refluent color atlas, use personal alkyl - ester of ester acerbity second - methanol - water (4:5: 3.5:5) is solvent system. Course high speed is refluent as a result color atlas rarefied, the quality mark of yew alcohol rises to 85.5 ﹪ by 5.1 ﹪ , reclaim rate achieve 98.6 ﹪ . Conclusion offerred a new approach for alcohol of yew of preparation tall purity.

Microbial changing is the enzymatic catalysis bottom that points to the generation in using microbial metabolization process content happening chemistry reacts, call microbial enzymatic law to change again, can apply directly microbial, usable also from microbial in of extraction enzymatic as activator. At present microbial change already applied at if a variety of medicaments are hormone of body of antibiotic, vitamin, steriod, amino acerbity, fragrant base third acid and prostate element the synthesis that wait [1] .