Plastid of yew mellow fat is to apply at fighting cancerous new drug clinically at present, fluid of inject of commonner yew alcohol provides plastid of yew mellow fat more advantage, the allergic risk that removed to be caused by menstruum, have add medicaments curative effect apparently, the good point that drops poisonous secondary action [1] . ～ applied internal medicine of breath of total hospital of Nanjing of Nanjing military region in May 2006 in October 2005 plastid of yew mellow fat and lung cancer of cellule of blame of therapy of combination blocking platinum 8, will nurse now experience reports as follows.
The purpose observes catalpa alcohol and small Bo are alkaline reach its conpatibility of medicines adipose cell dextrose uses up right Saimisong’s revulsive insulin resistance 3T3-L1, activation of object hyperplasia content oxidizes to accept put oneself in another’s position too in have a change of luck and this one process (PPAR- γ ) the influence that MRNA conveys. The method uses rice of ground a place of strategic importance model of cell of resistance of loose revulsive insulin, give ketone of Luo Ge row, small Bo alkaline, catalpa alcohol, catalpa alcohol respectively small Bo is alkaline undertake intervention, with dextrose oxidation enzymatic law detects wastage of the dextrose in fostering fluid, with 2- to oxigenate - [the rate of have a change of luck that 3H]-D- dextrose absorbs a law to observe dextrose, detect with RT-PCR the expression of PPAR- γ MRNA. Below the requirement that the result is contained or does not contain 10 nmol/L insulin, catalpa alcohol, small Bo is alkaline reach insulin of group of its conpatibility of medicines to resist the dextrose wastage of adipose cell and have a change of luck are led relatively model group is improved apparently (P ＜ 0.05, 0.01) , excel of effect of group of conpatibility of medicines is catalpa alcohol, small group of drug of Bo alkaline sheet (P ＜ 0.05, 0.01); and the expression of small Bo alkaline group and MRNA of γ of PPAR- of group of conpatibility of medicines is reduced (P ＜ 0.05, 0.01) . Conclusion catalpa alcohol, small Bo is alkaline all can increase dextrose to use up with have a change of luck, improve insulin resistance, its action does not depend on the existence of insulin, and small Bo is alkaline the expressive level that reachs two medicine conpatibility of medicines to still can reduce MRNA of γ of adipose cell PPAR- , clew catalpa alcohol, small Bo is alkaline likelihood and Luo Ge list the action mechanism that improves insulin resistance ketone is different.
Purpose preparation gives hydrochloric acid to rice of small Bo alkaline accept breeds and change property to undertake study to its manage. Nutmeg of methodological choice oily photograph is acerbity activator of different third ester, surface gets together oxygen ethylene castor oil and aid exterior activator glycerine, use bogus preparation of 3 yuan of phasor gives milk of rice of alkaline accept of hydrochloric acid small Bo. With 13 000 r/min, 30 min centrifugal stability and bead diameter are the evaluation index that accept rice breeds, use HPLC to determine the quantity with small alkaline Bo of the hydrochloric acid in accept rice breast, the main reason of diameter of potential of the viscosity that breeds to this accept rice at the same time, electrical conductivity, refractive index, Zeta, bead is changed property and tall wet (92.5 ﹪ ) , high temperature (40 ℃ , 60 ℃ ) , 25 ℃ and strong light [(the stability below the condition of 4 500 ± 500)lx] undertakes study. The milk of rice of alkaline accept of hydrochloric acid small Bo that result preparation gives is clear and transparent liquid, the observation below transmission report lens is bulbiform droplet, average bead diameter is 56.8 nm; centrifugal stability, 10 D makes an on-the-spot investigation below afore-mentioned tall wet, high temperature, strong smooth conditions, its contain dosage and bead diameter to all did not produce apparent change. Rice of alkaline accept of small Bo of conclusion hydrochloric acid breeds the good medicaments that is stability of a kind of quality transfers a system.
The purpose determines through parting mix with element of Mongolian oak skin in cottonseed extraction content hill Nai phenol is glucoside yuan the content of glucoside of two kinds of yellow ketone, ketone content always fizzles out in deciding cottonseed extracts content. Method with Mongolian oak Pi Su - 3-O- β - D- celery candy (α of 1 → 2)-[- L- buckthorn candy (β of 1 → 6)]- - naphthol of D- dextrose glucoside and hill - 3-O- β - D- celery candy (α of 1 → 2)-[- L- buckthorn candy (1 → 6)]- , use Shuang Bo to grow prismatic photometry, absorb in what 510nm and 410nm place determine below aluminous ionic existence degree, computation fizzles out two kinds the content of ketone glucoside. Glucoside of candy of element of skin of result Mongolian oak kind the linear limits of composition is 0 ～ Ml-1(r=0.999 6) of · of 6 × 10-2 Mg, reclaim rate for (glucoside of phenolic candy of Nai of hill of; of ﹪ of 98.96 ± 1.26) kind linear limits is 0 ～ Ml-1(r=0.999 
of · of 5.4 × 10-2 Mg, reclaim rate for (﹪ of 98.83 ± 1.29) . After the method avoided colour developing of glucoside of two kinds of yellow ketone, conclusion admits the test error that the difference of coefficient causes originally, determined to reflect the content that ketone composition fizzles out in cottonseed well and truly as a result.
Small Bo is alkaline (Berberine, BBR) is diabetes of cure of doctor of traditional Chinese medicine the main alkaloid in the rhizome of Chinese goldthread of commonly used medicine, have fall a variety of pharmacodynamics action such as fat of blood of blood sugar attune. The article was summarized in recent years domestic and international BBR falls the research of action of candy attune fat, release and basically secrete what pass stimulative insulin in the light of its, former different of refine sugar of the refreshment of rejuvenesce and function, sensitivity that heightens insulin, curb gives birth to β of stimulative pancreas islet and (or) the mechanism such as solution of stimulative candy ferment is reduced blood sugar and through promoting low density, fall for BBR the further research of candy attune fat and development application provide reference.
The purpose searchs Xiao Jiean capsule to contain alkaline move of small Bo of the hydrochloric acid in measuring methodological contribution wood to lead the account of on the low side. Methodological parallel compares contribution wood sheet tuckahoe of earth of decoct, take out and reticulate millettia decoction and shut simmer in water alkaline content of small Bo of the hydrochloric acid in wood of 3 kinds of contribution. Small Bo of 3 afore-mentioned experimental result hydrochloric acid are alkaline as a result content is ordinal reduce. Alkaline content of small Bo of the hydrochloric acid in conclusion contribution wood suffers the effect of a variety of elements.