Catalpa alcohol and small Bo are alkaline reach its conpatibility of medicines the influence Effect Of Catalpol of adipose cell of counteractive to insulin 3T3-L1, berberine, and Their Combination On Insulin Resistant 3T3-L1 Adipocytes
The purpose observes catalpa alcohol and small Bo are alkaline reach its conpatibility of medicines adipose cell dextrose uses up right Saimisong’s revulsive insulin resistance 3T3-L1, activation of object hyperplasia content oxidizes to accept put oneself in another’s position too in have a change of luck and this one process (PPAR- γ ) the influence that MRNA conveys. The method uses rice of ground a place of strategic importance model of cell of resistance of loose revulsive insulin, give ketone of Luo Ge row, small Bo alkaline, catalpa alcohol, catalpa alcohol respectively small Bo is alkaline undertake intervention, with dextrose oxidation enzymatic law detects wastage of the dextrose in fostering fluid, with 2- to oxigenate - [the rate of have a change of luck that 3H]-D- dextrose absorbs a law to observe dextrose, detect with RT-PCR the expression of PPAR- γ MRNA. Below the requirement that the result is contained or does not contain 10 nmol/L insulin, catalpa alcohol, small Bo is alkaline reach insulin of group of its conpatibility of medicines to resist the dextrose wastage of adipose cell and have a change of luck are led relatively model group is improved apparently (P ＜ 0.05, 0.01) , excel of effect of group of conpatibility of medicines is catalpa alcohol, small group of drug of Bo alkaline sheet (P ＜ 0.05, 0.01); and the expression of small Bo alkaline group and MRNA of γ of PPAR- of group of conpatibility of medicines is reduced (P ＜ 0.05, 0.01) . Conclusion catalpa alcohol, small Bo is alkaline all can increase dextrose to use up with have a change of luck, improve insulin resistance, its action does not depend on the existence of insulin, and small Bo is alkaline the expressive level that reachs two medicine conpatibility of medicines to still can reduce MRNA of γ of adipose cell PPAR- , clew catalpa alcohol, small Bo is alkaline likelihood and Luo Ge list the action mechanism that improves insulin resistance ketone is different.