Purpose: Teach? of kind of clam of cheese of carve Wo Deng α (TNF- α ) to collagen sex arthritis (the action of total glucoside of the influence of function of cell of CIA) bandicoot slippery film and root of herbaceous peony. Method: Model of IA of 驝 of ticket answer bed, separate training is normal bandicoot and CIA bandicoot joint become cell of fiber appearance slippery film (FLS) . Inspect TNF- α to be opposite when chroma of L-1 of · of G of μ of 0.02 ～ 20 the proliferous reaction of the normal bandicoot FLS of education and CIA bandicoot FLS and FLS secrete prostate element adenosine of phosphoric acid of E2(PGE2) , annulus (CAMP) and Bai Jiesu 1 β (IL-1 β ) influence, choose the optimal and exciting chroma of TNF- α . Observe different chroma (the total glucoside of root of herbaceous peony of · L-1) of 15.625 ～ 250 mg is opposite when the optimal and exciting chroma in TNF- α the proliferous reaction of CIA bandicoot FLS and FLS secrete PGE2, the influence of CAMP and IL-1 β . Detect with MTT law the proliferous reaction of FLS, radiative immunity mensuration detects PGE2, the level of CAMP and IL-1 β . Result: TNF- α all restrains normal bandicoot FLS and CIA bandicoot FLS to secrete CAMP significantly when the chroma of L-1 of · of 20 μ G, promote the exudation of PGE2 and IL-1 β significantly, the.TGP of optimal and exciting chroma that reason chooses L-1 of · of 20 μ G to be TNF- α can restrain α of L-1TNF- of · of 20 μ G significantly proliferous to the hurried of CIA bandicoot FLS reaction, go up apparently the CAMP level that tone reduces, reduce elevatory PGE2 and IL-1 β level apparently, and have certain chroma dependence. Conclusion: TNF- α can promote the hyperplasia of CIA bandicoot FLS, reduce CAMP, elevatory PGE2 and IL-1 β .TGP criterion the influence of α of TNF- of can apparent changeover to FLS.
Jiangsu will save 4 ～ in August 2003 saline city district appeared the urgent bellyacke patient of likeness of many clinical symptom, some villages and towns have 100 more than person to come on even [1] , have apparent seasonal and regional, see a doctor in villages and towns or prefectural courtyard mostly. Show pair of this institution 5 ～ received 26 when have diagnostic show when treat to undertake an analysis during November 2003, in order to discuss its because cause of disease of method of clinical feature, make a diagnosis and give treatment, hair reachs mechanism, report as follows now.
ASCO congress published an international much center 2007 Ⅲ period contrasts randomly the SHARP research result that treats liver cell cancer (LBAI) . This takes the lead by J.Lovet, the Ⅲ that includes the United States, Canada, Italy, France, Germany, Spain to attend period clinical research, enter in all the group is terminal, treat without the system, EC0G PS 0 ～ 2, Child-Pugh A period, the liver cell cancer that confirms via histology 602, among them 299 take all alone to pull blame Buddhist nun (Sorafenib)400 Mg bid, 303 are taken comfort an agent, terminus of main curative effect is always live period (OS) and semiotic progress time (Time To Symptomatic progression, TTSP) , less important terminus is progress time (TTP) and disease control rate (DCR, namely CR PR SD at least 2 periodic) .
Purpose: Qi of ∏ of triangular bream of fall from the sky of of tenon of Mou teaching childish not of scull of king crab of Zhao of P painful bed goes to Piao only then impossible of epiphysis of of eight Tao washing with watercolors goes to clam to embrace mire Yong? method: ⒚ of of of humorous of a small tinkling bell of Ai of ゲ of Mei of take along sth to sb considers Piao book to guess Qi of ∏ of triangular bream of Zhao of bed of ⒋ of of wash of king crab ⑸ not P? in group expression of Ⅳ of Collagen of composition of the matrix outside cell of observation kidney organization, FN, LN and content, changeover is recorded - aggregate enzymatic chain reaction (RT-PCR) method determines the gene of 1 conveys HGF and TGF- β . Result: Expression of gene of GF of P appropriate 镠 drops apparently, 1 expression of TGF- β rises. Composition of the matrix outside the cell is remarkable grow in quantity. Kidney scanty peace treats expression of group HGF gene to rise, 1 gene expression reduces TGF- β . Conclusion: The balance that 1 gene of GF of 贖 of Gu of Nai of Mou tenon and TGF- β conveys, reduce increase of the matrix outside the cell, progress of sclerosis of spherule of kidney of prevention and cure is significant.
The medicaments fighting impaludism that green Hao element is the efficient, low poison that gets from the depart in Hao of chrysanthemum of traditional Chinese herbal medicine, had contained compound of the ester inside the times half terpene of oxidation radical group for a kind, its ramification includes ester of Hu of ether of Hao armour aether, Hao, Qing Hao, Shuangqing green Hao element.
Polysaccharide of purpose observation the root of remembranous milk vetch (total glucoside of Astragalus Polysaccharide) and root of herbaceous peony (the fat inside cell of bubble of sex of source of cell of huge to THP-1 bite affects Total Glucosides Of paeony) and its conpatibility of medicines character, from restrain the fat inside huge bite cell to collect angle to discuss Chinese traditional medicine character of active ingredient fight mechanism of sclerosis of arterial congee appearance. Methodological application microscope is photographed analyse software to measure a quantity to be fostered without ApoA-I surely partly like technology and graph base / ApoA-I is fostered base in the content with the qualitative fat inside cell of bubble of sex of source of cell of THP-1 huge bite. The result does not have ApoA-I the cholesterol inside cell of bubble of group of group of the root of remembranous milk vetch in education radical, conpatibility of medicines area ratio of fat qualitative coloring contrasts group of apparent increase (P ＜ 0.05);apoA-I is fostered base in cholesterol of group of group of root of herbaceous peony, conpatibility of medicines area ratio of fat qualitative coloring contrasts the group is apparent decrease (P ＜ 0.05) . Polysaccharide of conclusion the root of remembranous milk vetch can enhance lipoprotein of pair of oxidation low density gobble up ability, total glucoside of root of herbaceous peony can promote outflow of the cholesterol inside the cell. Conpatibility of medicines of total glucoside of polysaccharide of the root of remembranous milk vetch and root of herbaceous peony (12 ∶ 1) has fight action of sclerosis of arterial congee appearance potentially.
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