Week vein buy enters central vein conduit outside (PICC) is in at present as a kind of new-style venipuncture technology place of the personnel that be protected by each cure of large hospital is accepted, it gives not only nurse the operation was brought convenient, the patient that undertakes vein injects more for a long time repeatedly reduced anguish. The medicaments that change cure because the its chemistry sex, acidity and high concentration ooze outside causing blood capillary to connect the heighten that appear a gender to send medicaments, easy cause hemal injury to reach cause local organization necrotic with acuteness ache, PICC conduit solved this one difficult problem with its distinct advantage, but infection may be the main complication that places conduit, because this management to PICC cut is attached most importance to especially,want [1] .
Composition of cholic acid of inject fluid Central Africa is opposite purpose research Qing Kailing cholic acid (CA) and different deoxygenate cholic acid (the influence that acting kinetic process reachs HDCA) medicine to distributing in main internal organs of the body, open the pharmacodynamics action of quick injection fluid in order to clarify clear. Methodological test animal divides 2 groups, qing Dynasty opens quick injection fluid (the CA/HDCA form that group of 10ml · Kg-1) and sheet use same dose, small rat is abstinence before giving drug can’t help water 12h, orbit minim collects blood 20 μ L, after oscillation of direct precipitation albumen centrifugal, take Qing Dynasty to detect into appearance. Metage of filter paper blot is used after taking heart, lung, kidney, head to clean, use 4 divide evenly of 1 ∶ oar hind is centrifugal take Qing Dynasty, the processing technique detects into appearance with hematic sample. Color atlas of use fluid photograph / usage of mass spectra couplet detects blood and the content that organize the CA in sample and HDCA. Result CA and HDCA are mixed in complete blood the limits of medicaments chroma linear in the organization is L-1 of · of μ G of 4 ～ 4 000, linear relationship is good (R ＞ 0.999) , lowest detects chroma is L-1 of · of 2 μ G, daytime and the RSD of the precision inside day all ＜ 5 ﹪ . Acting kinetic parameter mixes the drug that compares the CA when medicine made of two or more ingredients counteracts sheet to use and HDCA basically organizing (heart, lung, kidney, head) distributing mediumly, β of the AUC that Qing Dynasty opens the CA in quick injection fluid and HDCA, MRT, T1/2, V all when sheet of apparent prep above is used (P ＜ 0.05) , when CL is used under sheet apparently (of the CA in fluid of inject of Qing Kailing of P ＜ 0.05); and HDCA distributing apparent excel sheet uses CA/HDCA, CA and HDCA are in the distributinging characteristic in the organization: CHead of C of ＞ of heart of C of ＞ of kidney of lobar ＞ C. Conclusion this methodological sensitivity is tall, particularity is good, composition of cholic acid of Central Africa of fluid of inject of Qing Kailing of; of research of the process inside the body that applies to cholic acid apperception to close matter can lengthen cholic acid composition the distributinging;CA in the organization and HDCA are in the detention time inside body and composition of stimulative cholic acid low specification of the chroma in the head its pass through hematic head not easily.