New drug considers to develop cost and Analysis Of The Cost And Influence Factors Of New Drug R
Uterine flesh tumour is the benign tumor with female genital most common lawsuit, good hair at Yo age woman. Although flesh tumour itself is much,have a symptom rarely, but wait because of flesh tumour position and denaturation bring about an uterus abnormal haemorrhage, afterwards sends severe anemia, pelvic cavity oppressive symptom and ache, make one of main reasons that uterine flesh tumour makes hysterectomy.
Fern, call bracken the plant again, be a flock of is in kind of spore plant that all has diversity with metabolization respect character, in plant system they upright to be mixed at bryophyte between spermatophyte. Whole world fern has 12 thousand about a variety of, distributing extensively at world each district, abound most with tropics and semi-tropical area, happy event grow at the silvan region with warm wet nether world, china has 2600 about a variety of, it is the brake on the world kind one of areas with the most substantial natural resources, occupy the 1/5[1] of world sum total about.
Nettle is resourceful Chinese herbal medicine. The main pharmacodynamics action that already discovered nettle now includes to fall blood sugar, fight phlogistic analgesia, fall blood pressure, fight benign prostate hyperplasia, fight oxidation, fight tumor and adjust airframe immunity, fight poison of bacterium, disease-resistant to wait. The article is domestic and international in last few years nettle belongs to floral pharmacodynamics action to make one overview, to develop development new drug provides a basis.
The purpose considers to HBV active part is refused in careless Alternanthera Philoxeroides of hollow lotus seed. The method departs with color atlas of silica gel column, gel column, preparation HPLC is rarefied, use the spectrum method such as MS, NMR to undertake structural appraisal; uses ELISA law to undertake to each compound active detects fighting HBV. The result departs from inside grass of hollow lotus seed appraisal 10 compound, it is acid of neat mound fruit respectively (Oleanolic acid, Ⅰ ) , 3-O- β - dextrose of D- Bi Nan acerbity glucoside of fruit of aldehyde radical neat mound (Oleanolic Acid 3-O- β - D-glucuronopyranoside, Ⅱ ) , neat mound fruit is acerbity - 28-O- β - dextrose glucoside of D- Bi Nan (Oleanolic Acid 28-O- β - D-glucopyranoside, Ⅲ ) , ester of armour of A of Ⅳ of rings ginseng glucoside (A Methyl ester of Chikusetsusaponin Ⅳ , Ⅳ ) , 4, 5-dihydroblumenol (Ⅴ ) , N-trans-feruloyl 3-methyldopamine(Ⅵ ) , N-trans-feruloyl tyramine(Ⅶ ) , 3 β - hydroxyl beans steriod - 5- Xi - 7- ketone (3 β - Hydrox-ystigmast-5-en-7-one, Ⅷ ) , the court of a feudal ruler of 24 Er of methylene annulus A are mellow (24-methylenecycloartanol, Ⅸ ) , annulus eucalyptus Xi is mellow (Cycloeucalenol, Ⅹ ) . Fight HBV active to choose make clear, Ⅲ of compound Ⅰ ~ , Ⅴ ~ Ⅶ is had fight HBV active apparently, compound Ⅱ and Ⅴ give drug in 50 μ G/mL caught person liver cancer cell turns to HBV-DNA clone when the quantity of HepG2-2.2.15 restrain rate mix for 85.38 ﹪ respectively 87.37 ﹪ . Conclusion compound Ⅳ ~ Ⅶ shares from inside this plant first, compound of asafoetida acyl amine is the structural type that shares from inside should belong to a plant first, compound Ⅰ and Ⅴ are had stronger fight HBV active.
The purpose considers to plan to lack the chemical ingredient of Rabdosia Excisoides of sweet tea food. The method uses law of color atlas of silica gel column to undertake departing mixing rarefied, learn to analyse structure of appraisal monomer compound through chart. Result from plan to lack identification of depart of sweet tea food 2 compound, compound Ⅰ names to plan to lack element of armour of sweet tea food (appraisal of Excisoidesin A); compound Ⅱ is Qi Dunguo acid. What Ⅰ is conclusion compound to discover first is new 2 terpene composition.
The purpose considers to suffer from the chemical composition of wooden alkaloid. The method undertakes with silica gel and Sephadex LH-20 chromatographic column departs, change structure of appraisal of property, spectral data through manage. Result appraisal 16 alkaloid, it is respectively: 5- armour oxygen base - ketone of iron excrement rice (Ⅰ ) , 11- hydroxyl - ketone of iron excrement rice (Ⅱ ) , ketone of iron excrement rice (Ⅲ ) , 4, 2 armour of 5- oxygen radical - ketone of iron excrement rice (Ⅳ ) , 4- armour oxygen base - 5- hydroxyl - ketone of iron excrement rice (Ⅴ ) , 3- is methylic - iron excrement rice - 2, 2 ketone of 6- (Ⅵ ) , 1- armour acyl - 4- armour oxygen base - β - Ka cling to Lin (Ⅶ ) , 1- armour oxygen base - β - Ka cling to Lin (Ⅷ ) , 1- second base - 4, 2 armour of 8- oxygen radical - β - Ka cling to Lin (Ⅸ ) , acyl of armour of 1- armour oxygen - 4- hydroxyl - β - Ka cling to Lin (Ⅹ ) , 1- is methylic - 4- armour oxygen base - β - Ka cling to Lin (Ⅺ ) , 1- second oxygen, 2, 3, 4-tetrahydro-1, 3, 4-trioxo- β - ) of Carboline(Ⅹ Ⅵ . Conclusion compound Ⅺ is get from the depart in nature plant first, Ⅴ of compound Ⅱ , Ⅷ , Ⅹ is belong to the depart in the plant to get from this first.
Contemporary pharmacological considers to make clear, glucoside of red red-spotted stonecrop has the active part that red red-spotted stonecrop belongs to place of plant red red-spotted stonecrop to contain to be fought significantly exhaustion and fight anoxic action, it is to study development fights exhaustion at present, fight the anoxic, important raw material that fights anile medicaments and health care to taste [1] . Red red-spotted stonecrop belongs to plant whole world to have more than kinds 90, our country has 70 a variety of. Basically distributing to reach southwest and other places at northeast, China north, northwest, the Xinjiang that is in our country, Tibet also has distributing. As a result of producing area different, breed differs, quantity of glucoside of red red-spotted stonecrop also has different [2, 3] . This experiment used HPLC law to determine the quantity of glucoside of red red-spotted stonecrop in rootstock of 7 kinds of of area of Sichuan, Xinjiang, Tibet red red-spotted stonecrop [4] , among them some breed are to report first, mix to make an on-the-spot investigation reasonable the resource of red red-spotted stonecrop that uses our country to abound provides a basis.
The purpose considers to order the chemical part of bacterium of handle milker liver, undertake to the compound of detached appraisal the active of HIV-1 studies fighting. The substance of mushroom of liver of the milker that nod a handle that the method collects field uses solvent to extract, use color atlas of silica gel column to undertake depart, adopt spectrum technique (NMR, MS, IR) have identification to the structure. Result depart appraisal 9 compound, it is respectively: Ⅰ of garden ? ) , 5a, 8a- crosses oxygen ergot steriod - 6, 2 Xi of 22- - 3 β - mellow (Ⅱ ) , ergot steriod - 5, 7, 3 Xi of 22- - 3 β - mellow (Ⅲ ) , ergot steriod - 5, 7, 3 Xi of 22- - 3 β - O- β - dextrose glucoside of D- Bi Nan (Ⅳ ) , uric pyrimidine (Ⅴ ) ) , acid anhydride of sulfur Dai Yi (Ⅵ ) , tristearin is acerbity (Ⅶ ) , 3- pyridine formic acid (Ⅷ ) with D- A Luo sugar alcohol. Ⅰ is conclusion compound to depart from inside advanced fungus first. Classics biology active checks, this compound is had fight HIV-1 active, lesser to the noxiousness of C8166 cell, CC50 is 87.86 μ G/mL, cell of revulsive to HIV-1 C8166 forms EC50 of low-key of body adding up to afterbirth to be G/mL of 7.27 μ , remedial index (TI is worth) for 12.09.
Powered by WordPress