Herbal Medicine

Purpose application medicine is moved learn to learn to combine a model with medical effect, watch of the bases in total alkaloid of research board blue root is accused according to spring the medicine inside body of the yeasty bandicoot that send heat is moved learn to learn the relation between with medical effect. The method gives bandicoot total alkaloid of Ig board blue root, different time takes blood and have observation to temperature, use doctrine of concentrated juice look to determine the watch in plasma is accused according to spring chroma, with model of one room room computational medicine is moved learn parameter, use 3 kinds of medicine to move learn to learn to plan to combine a model with medical effect, learn parameter to undertake planning to close to medical effect respectively. As a result the watch is accused according to spring the main medicine inside normal bandicoot and calorific bandicoot body is moved learn parameter T1/2, Cmax, AUC to be respectively: (4.94 ± 0.84)h, (G/mL of μ of 4.01 ± 0.21) , (H/mL of · of G of μ of 28.37 ± 2.42) and (5.71 ± 0.91)h, (G/mL of μ of 4.15 ± 0.25) , (H/mL of · of G of μ of 30.35 ± 2.58) . It is better that the relation between pharmacodynamics effect and effect room chroma uses the medical effect generation in indirect reaction to restrain a model to plan to close, corresponding medical effect learns parameter to be for Kin respectively (0.7 ± 0.10)h-1, kout is (0.54 ± 0.12)h-1, r0 is 1.33 ± 0.16, IC50 is (0.94 ± 0.66)mg/L. The watch in total alkaloid of conclusion board blue root is accused according to spring the medicine inside normal bandicoot and calorific bandicoot body is moved learn behavior not to have apparent difference, the watch is accused according to spring inside calorific bandicoot body medicine is moved learn to learn a medical effect generation in according with indirect reaction to restrain a model with medical effect.